Jaguars receiver Christian Kirk left with a groin injury after collecting a 26-yard Trevor Lawrence pass on the first play.
Kirk, who has 56 receptions for 761 yards and three scores this season, is questionable to return.
Travis Etienne's 4-yard run provides a touchdown on the same drive despite Kirk's injury.
Late in the second quarter, Bengals' Sam Hubbard sacks Trevor Lawrence, forcing a 3-and-out.
Joe Mixon's 33 yards and two scores on eight attempts help the Bengals' balanced offense.
Bengals quarterback Jake Browning completes 17-of-19 passes for 178 yards.
The Bengals want to maintain their offensive pace and create defensive mistakes.
As fantasy season progresses, the analysis highlights players rising or falling.