The Miami Heat are playing their league-leading 12th away game despite a 10-6 record.
Recent collapses, including a second 21-point loss to the Knicks, hurt the Heat's record.
Heat blew a big lead by scoring 11 points in the fourth quarter and shooting 3-of-21.
Spoelstra said, "There’s a karma to it, and we ended up paying the price for that."
Jimmy Butler scored 23 points but went 0-for-5 in the pivotal fourth quarter.
Butler believes the recent collapses are the last but worries about future leads slipping away.
The Heat lost 109-105 to the Nets on Nov. 1 after leading by 16 points.
Brooklyn lost three straight, including a wild 147-145 overtime loss to Atlanta.